Treatment needs to be exercised by people who are also taking protease inhibitors for your treatment of HIV infection. Protease inhibitors inhibit the metabolism of sildenafil, successfully multiplying the plasma levels of sildenafil, expanding the incidence and severity of Unwanted effects.
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The use of sildenafil and an αone blocker (normally prescribed for hypertension or for urologic ailments, like benign prostatic hypertrophy) at the same time might result in small blood pressure, but this impact will not take place If they're taken at the very least 4 several hours aside.[sixteen] Contraindications
Grapefruit and grapefruit juice may well communicate with sildenafil and lead to undesired Unwanted effects. Stay clear of using grapefruit merchandise though getting Viagra.
Tend not to choose Viagra In case you are also employing a nitrate drug for chest soreness or heart difficulties. This includes nitroglycerin, isosorbide dinitrate, and isosorbide mononitrate.
Get hold of your health care provider or search for emergency clinical interest If the erection is painful or lasts for a longer period than 4 hours. A protracted erection (priapism) can hurt the penis.
In The us, Pfizer obtained pde-5 two patents for sildenafil: one for its indication to take care of cardiovascular disease (marketed as Revatio) and One more for its sign to deal with erectile dysfunction (promoted as Viagra). The compound is similar less than the two trade names.[75]
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Its use has become among the list of regular treatment plans for erectile dysfunction, which include for men with diabetes mellitus.[six] Antidepressant-affiliated sexual dysfunction
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Though sildenafil increases some markers of sickness in those with pulmonary arterial hypertension, it does not seem to have an affect on the risk of Demise or really serious side effects as of 2014[update].[8] Raynaud's phenomenon